In this project, we aim to develop a thorough understanding of polyurethanes (PU) in coating applications in dry environments and as interacting with water. The project aims at using computational methods and state-of-the-art simulation tools to develop a thorough understanding of polyurethane (PU) polymer as well as performing parallel experimental studies to validate the simulations. By performing computational simulation methods and employing molecular simulations at different time and length scales, we aim to study the correlation between the chemical structure of the Polyurethane (PU) network and the dynamics of rearrangements at the water interface. Moreover, we synthetize similar PU systems and study the macroscopic polymer/water interactions in the lab to confirm our understanding from simulation studies. Therefore, our project fits in the area of “idea to application” and based on the results of our research, new commercial coatings can be developed.